Enhancement of solubility, dissolution rate and bioavailability of active compound is a very challenging task with a great relevance in active compound development and formulation for pharmaceutical, cosmetic and food industries.Among all newly discovered chemical entities about 40% drug are lipophilic. These poorly water soluble drugs having slow drug absorption leads to inadequate and variable bioavailability and gastrointestinal mucosal toxicity. For these reasons is necessary a good formulation in order to increase the solubility, availability at the site of action, maintaining the stability of active compound.
Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug. These technology may have various disadvantages so best technique is selected on the basis of physical and chemical property of the drug and other physico-chemical property of the drug. Following are the various techniques that are used to improve solubility:
- COMPLEXATION TECHNIQUES
- CLATHRATES
- ALTERATION IN THE pH OF SOLVENT
- SALT FORMATION
- HYDROTROPIC SOLUBILIZATION
- MICELLER SOLUBILIZATION BY SURFACTANTS
- MICRONIZATION
- SOLID SOLUTION
- SOLID DISPERSION
- FAST DISSOLVING PRODUCTS
- FREEZE DRYING
- COSOLVENCY
- POLYMORPHISM
- MULTIFLUID NOZZLE SPRAY DRYING
- LIPID BASED DRUG DELIVERY SYSTEM
- MOLECULAR ENCAPSULATION
- SELECTIVE ADSOPTION
- SUPERSATURATED DRUG DELIVERY SYSTEM
- PRODRUG
- Cavitation & Melt Sono-Cryatallization
The complete article can be viewed in: Solubility enhancement technique
Author- Ajit Jha
Tags:
Formulation